Gadolinium conjugated TiO(2)-DNA oligonucleotide nanoconjugates show prolonged intracellular retention period and T(1)-weighted contrast enhancement in Magnetic Resonance images

Nanoconjugates composed of TiO(2) nanoparticles, DNA oligonucleotides and a gadolinium contrast agent were synthesized for use in magnetic resonance imaging. Transfection of cultured cancer cells with these nanoconjugates showed them to be superior to the free contrast agent of same formulation with...

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Hauptverfasser: Paunesku, Tatjana, Ke, Tianyi, Dharmakumar, Rohan, Mascheri, Nicole, Wu, Aiguo, Lai, Barry, Vogt, Stefan, Maser, Jörg, Thurn, Kenneth, Szolc-Kowalska, Barbara, Larson, Andrew, Bergan, Raymond C, Omary, Reed, Li, Debiao, Lu, Zheng-Rong, Woloschak, Gayle E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663023/
https://ncbi.nlm.nih.gov/pubmed/18567541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2008.04.004
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