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Differential Activities of the Ubiquitin–Proteasome System in Neurons versus Glia May Account for the Preferential Accumulation of Misfolded Proteins in Neurons

A variety of neurological disorders and polyglutamine (polyQ) diseases are caused by misfolded proteins. The common feature of these diseases is late-onset cellular degeneration that selectively affects neurons in distinct brain regions. polyQ diseases, including Huntington's disease (HD), pres...

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מידע ביבליוגרפי
Main Authors: Tydlacka, Suzanne, Wang, Chuan-En, Wang, Xuejun, Li, Shihua, Li, Xiao-Jiang
פורמט: Artigo
שפה:Inglês
יצא לאור: Society for Neuroscience 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662777/
https://ncbi.nlm.nih.gov/pubmed/19052220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4393-08.2008
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