Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice

Regulation of the formation and function of bone-resorbing osteoclasts (OCs) is a key to understanding the pathogenesis of skeletal disorders. Gene-targeting studies have shown that the RANK signaling pathway plays a critical role in OC differentiation and function. Although pharmaceutical blockade...

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Bibliografiske detaljer
Main Authors: Kim, Hyunsoo, Choi, Han Kyoung, Shin, Ji Hye, Kim, Kyung Hee, Huh, Ji Young, Lee, Seung Ah, Ko, Chang-Yong, Kim, Han-Sung, Shin, Hong-In, Lee, Hwa Jeong, Jeong, Daewon, Kim, Nacksung, Choi, Yongwon, Lee, Soo Young
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662555/
https://ncbi.nlm.nih.gov/pubmed/19258703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36809
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