Plasma membrane Ca(2+)-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents

How Ca(2+)-dependent signaling effectors are regulated in cardiomyocytes, given the extreme cytoplasmic Ca(2+) concentration changes that underlie contraction, remains unknown. Cardiomyocyte plasma membrane Ca(2+)-ATPase (PMCA) extrudes Ca(2+) but has little effect on excitation-contraction coupling...

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Bibliografiska uppgifter
Huvudupphovsmän: Wu, Xu, Chang, Baojun, Blair, N. Scott, Sargent, Michelle, York, Allen J., Robbins, Jeffrey, Shull, Gary E., Molkentin, Jeffery D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2009
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662553/
https://ncbi.nlm.nih.gov/pubmed/19287093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36693
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