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Plasma membrane Ca(2+)-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents

How Ca(2+)-dependent signaling effectors are regulated in cardiomyocytes, given the extreme cytoplasmic Ca(2+) concentration changes that underlie contraction, remains unknown. Cardiomyocyte plasma membrane Ca(2+)-ATPase (PMCA) extrudes Ca(2+) but has little effect on excitation-contraction coupling...

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Autori principali: Wu, Xu, Chang, Baojun, Blair, N. Scott, Sargent, Michelle, York, Allen J., Robbins, Jeffrey, Shull, Gary E., Molkentin, Jeffery D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662553/
https://ncbi.nlm.nih.gov/pubmed/19287093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36693
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