The TEL-AML1 leukemia fusion gene dysregulates the TGF-β pathway in early B lineage progenitor cells

Chromosome translocation to generate the TEL-AML1 (also known as ETV6-RUNX1) chimeric fusion gene is a frequent and early or initiating event in childhood acute lymphoblastic leukemia (ALL). Our starting hypothesis was that the TEL-AML1 protein generates and maintains preleukemic clones and that con...

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Main Authors: Ford, Anthony M., Palmi, Chiara, Bueno, Clara, Hong, Dengli, Cardus, Penny, Knight, Deborah, Cazzaniga, Giovanni, Enver, Tariq, Greaves, Mel
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662549/
https://ncbi.nlm.nih.gov/pubmed/19287094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36428
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