TRAF6 and MEKK1 Play a Pivotal Role in the RIG-I-like Helicase Antiviral Pathway

Type I interferons (IFN-α/β) are essential for immune defense against viruses and induced through the actions of the cytoplasmic helicases, RIG-I and MDA5, and their downstream adaptor molecule IPS-1. TRAF6 and the downstream kinase TAK1 have been shown to be essential for the production of proinfla...

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Detalles Bibliográficos
Main Authors: Yoshida, Ryoko, Takaesu, Giichi, Yoshida, Hideyuki, Okamoto, Fuyuki, Yoshioka, Tomoko, Choi, Yongwon, Akira, Shizuo, Kawai, Taro, Yoshimura, Akihiko, Kobayashi, Takashi
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662295/
https://ncbi.nlm.nih.gov/pubmed/18984593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806576200
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