TRAF6 Is Required for Generation of the B-1a B Cell Compartment as well as T Cell-Dependent and -Independent Humoral Immune Responses

TNF receptor superfamily members, such as CD40 and the Toll-like receptors (TLRs), regulate many aspects of B cell differentiation and activation. TRAF6 is an intracellular signaling adaptor molecule for these receptors, but its role in B cells has not been clarified by previous genetic approaches,...

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Detalhes bibliográficos
Main Authors: Kobayashi, Takashi, Kim, Tae Soo, Jacob, Anand, Walsh, Matthew C., Kadono, Yuho, Fuentes-Pananá, Ezequiel, Yoshioka, Tomoko, Yoshimura, Akihiko, Yamamoto, Masahiro, Kaisho, Tsuneyasu, Akira, Shizuo, Monroe, John G., Choi, Yongwon
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650412/
https://ncbi.nlm.nih.gov/pubmed/19270748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004736
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