The Solution Structure of DNA-free Pax-8 Paired Box Domain Accounts for Redox Regulation of Transcriptional Activity in the Pax Protein Family

Pax-8 is a transcription factor belonging to the PAX genes superfamily and its crucial role has been proven both in embryo and in the adult organism. Pax-8 activity is regulated via a redoxbased mechanism centered on the glutathionylation of specific cysteines in the N-terminal region (Cys(45) and C...

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Main Authors: Codutti, Luca, van Ingen, Hugo, Vascotto, Carlo, Fogolari, Federico, Corazza, Alessandra, Tell, Gianluca, Quadrifoglio, Franco, Viglino, Paolo, Boelens, Rolf, Esposito, Gennaro
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2008
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662260/
https://ncbi.nlm.nih.gov/pubmed/18829450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805717200
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