Nuclear Protein Tyrosine Phosphatase Shp-2 Is One Important Negative Regulator of Nuclear Export of Telomerase Reverse Transcriptase

Aging is one major risk factor for numerous diseases. The enzyme telomerase reverse transcriptase (TERT) plays an important role for aging and apoptosis. Previously, we demonstrated that inhibition of oxidative stress-induced Src kinase family-dependent nuclear export of TERT results in delayed repl...

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Bibliografiske detaljer
Main Authors: Jakob, Sascha, Schroeder, Peter, Lukosz, Margarete, Büchner, Nicole, Spyridopoulos, Ioakim, Altschmied, Joachim, Haendeler, Judith
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662250/
https://ncbi.nlm.nih.gov/pubmed/18829466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805138200
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