Crystal Structure of Filamentous Aggregates of Human DJ-1 Formed in an Inorganic Phosphate-dependent Manner

Mutations in the DJ-1 gene have been implicated in the autosomal recessive early onset parkinsonism. DJ-1 is a soluble dimeric protein with critical roles in response to oxidative stress and in neuronal maintenance. However, several lines of evidence suggest the existence of a nonfunctional aggregat...

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Bibliografiske detaljer
Main Authors: Cha, Sun-Shin, Jung, Ha Il, Jeon, Hyesung, An, Young Jun, Kim, In-Kwon, Yun, Sanguk, Ahn, Hyun Jin, Chung, Kwang Chul, Lee, Sang Hee, Suh, Pann-Ghill, Kang, Sa-Ouk
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662228/
https://ncbi.nlm.nih.gov/pubmed/18922803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804243200
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