SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy

Dysregulated autophagy is associated with steatosis and non-alcoholic fatty liver disease (NAFLD), however the mechanisms connecting them remain poorly understand. Here, we show that co-administration of lovastatin and ezetimibe (L/E) significantly reverses hepatic triglyceride accumulation concomit...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Kim, Kwang-Youn, Jang, Hyun-Jun, Yang, Yong Ryul, Park, Kwang-Il, Seo, JeongKon, Shin, Il-Woo, Jeon, Tae-Il, Ahn, Soon-cheol, Suh, Pann-Ghill, Osborne, Timothy F., Seo, Young-Kyo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5073315/
https://ncbi.nlm.nih.gov/pubmed/27767079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35732
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