Substitutions in the aspartate transcarbamoylase domain of hamster CAD disrupt oligomeric structure
Aspartate transcarbamoylase (ATCase; EC 2.1.3.2) is one of three enzymatic domains of CAD, a protein whose native structure is usually a hexamer of identical subunits. Alanine substitutions for the ATCase residues Asp-90 and Arg-269 were generated in a bicistronic vector that encodes a 6-histidine-t...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26622/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10618377/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.1.97 |
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