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Phytophthora infestans Dihydroorotate Dehydrogenase Is a Potential Target for Chemical Control – A Comparison With the Enzyme From Solanum tuberosum

The oomycete Phytophthora infestans is the causal agent of tomato and potato late blight, a disease that causes tremendous economic losses in the production of solanaceous crops. The similarities between oomycetes and the apicomplexa led us to hypothesize that dihydroorotate dehydrogenase (DHODH), t...

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Principais autores: Manuel F. Garavito, Heidy Y. Narvaez-Ortiz, Dania Camila Pulido, Monika Löffler, Howard S. Judelson, Silvia Restrepo, Barbara H. Zimmermann
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-06-01
coleção:Frontiers in Microbiology
Assuntos:
dihydroorotase dehydrogenase
inhibitors
pyrimidine biosynthesis
Phytophthora infestans
Solanum tuberosum
kinetics
Acesso em linha:https://www.frontiersin.org/article/10.3389/fmicb.2019.01479/full
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