Human Glyceraldehyde-3-phosphate Dehydrogenase Plays a Direct Role in Reactivating Oxidized Forms of the DNA Repair Enzyme APE1

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has diverse biological functions including its nuclear translocation in response to oxidative stress. We show that GAPDH physically associates with APE1, an essential enzyme involved in the repair of abasic sites in damaged DNA, as well as in the redo...

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Detalhes bibliográficos
Main Authors: Azam, Sonish, Jouvet, Nathalie, Jilani, Arshad, Vongsamphanh, Ratsavarinh, Yang, Xiaoming, Yang, Stephen, Ramotar, Dindial
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662153/
https://ncbi.nlm.nih.gov/pubmed/18776186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801401200
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