Activation Mechanism of Recombinant Der p 3 Allergen Zymogen: CONTRIBUTION OF CYSTEINE PROTEASE Der p 1 AND EFFECT OF PROPEPTIDE GLYCOSYLATION

The trypsin-like protease Der p 3, a major allergen of the house dust mite Dermatophagoides pteronyssinus, is synthesized as a zymogen, termed proDer p 3. No recombinant source of Der p 3 has been described yet, and the zymogen maturation mechanism remains to be elucidated. The Der p 3 zymogen was p...

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Detalhes bibliográficos
Main Authors: Dumez, Marie-Eve, Teller, Nathalie, Mercier, Frédéric, Tanaka, Tetsuya, Vandenberghe, Isabel, Vandenbranden, Michel, Devreese, Bart, Luxen, André, Frère, Jean-Marie, Matagne, André, Jacquet, Alain, Galleni, Moreno, Chevigné, Andy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662151/
https://ncbi.nlm.nih.gov/pubmed/18725410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803041200
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