The Human Cathelicidin LL-37 Modulates the Activities of the P2X(7) Receptor in a Structure-dependent Manner

Extracellular ATP, released at sites of inflammation or tissue damage, activates the P2X(7) receptor, which in turn triggers a range of responses also including cell proliferation. In this study the ability of the human cathelicidin LL-37 to stimulate fibroblast growth was inhibited by commonly used...

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Hauptverfasser: Tomasinsig, Linda, Pizzirani, Cinzia, Skerlavaj, Barbara, Pellegatti, Patrizia, Gulinelli, Sara, Tossi, Alessandro, Virgilio, Francesco Di, Zanetti, Margherita
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Membrane Transport, Structure, Function, and Biogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662141/
https://ncbi.nlm.nih.gov/pubmed/18765670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802185200
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