IFN consensus sequence binding protein potentiates STAT1-dependent activation of IFNγ-responsive promoters in macrophages

IFNγ, once called the macrophage-activating factor, stimulates many genes in macrophages, ultimately leading to the elicitation of innate immunity. IFNγ's functions depend on the activation of STAT1, which stimulates transcription of IFNγ-inducible genes through the GAS element. The IFN consens...

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Bibliographic Details
Main Authors: Contursi, Cristina, Wang, I-Ming, Gabriele, Lucia, Gadina, Massimo, O'Shea, John, Morse, Herbert C., Ozato, Keiko
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2000
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC26621/
https://ncbi.nlm.nih.gov/pubmed/10618376
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