STAT4 serine phosphorylation is critical for IL-12-induced IFN-γ production but not for cell proliferation

T helper 1 (T(H)1) differentiation and IFN-γ production are crucial in cell-mediated immune responses. IL-12 is an important regulator of this process and mediates its effects through signal transducer and activator of transcription 4 (STAT4). IFN-γ production is also regulated by the p38 mitogen-ac...

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Autori principali: Morinobu, Akio, Gadina, Massimo, Strober, Warren, Visconti, Roberta, Fornace, Albert, Montagna, Cristina, Feldman, Gerald M., Nishikomori, Ryuta, O'Shea, John J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2002
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC129436/
https://ncbi.nlm.nih.gov/pubmed/12213961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.182618999
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