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STAT4 serine phosphorylation is critical for IL-12-induced IFN-γ production but not for cell proliferation
T helper 1 (T(H)1) differentiation and IFN-γ production are crucial in cell-mediated immune responses. IL-12 is an important regulator of this process and mediates its effects through signal transducer and activator of transcription 4 (STAT4). IFN-γ production is also regulated by the p38 mitogen-ac...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC129436/ https://ncbi.nlm.nih.gov/pubmed/12213961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.182618999 |
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