15-Deoxy-Δ(12,14)-prostaglandin J(2) Induces Vascular Endothelial Cell Apoptosis through the Sequential Activation of MAPKS and p53

15-Deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)) is a potent anti-angiogenic factor and induces endothelial cell apoptosis, although the mechanism remains unclear. In this study, 15d-PGJ(2) was found to increase p53 levels of the human umbilical vein endothelial cells by stabilizing p53. Both 15d-P...

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Main Authors: Ho, Tsung-Chuan, Chen, Show-Li, Yang, Yuh-Cheng, Chen, Chia-Yi, Feng, Fang-Ping, Hsieh, Jui-Wen, Cheng, Huey-Chuan, Tsao, Yeou-Ping
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2008
主題:
Mechanisms of Signal Transduction
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662083/
https://ncbi.nlm.nih.gov/pubmed/18718914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804196200
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