Functional Adhesiveness of the CX3CL1 Chemokine Requires Its Aggregation: ROLE OF THE TRANSMEMBRANE DOMAIN

In its native form, the chemokine CX3CL1 is a firmly adhesive molecule promoting leukocyte adhesion and migration and hence involved, along with its unique receptor CX3CR1, in various inflammatory processes. Here we investigated the role of molecular aggregation in the CX3CL1 adhesiveness. Assays of...

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Detalhes bibliográficos
Main Authors: Hermand, Patricia, Pincet, Frédéric, Carvalho, Stéphanie, Ansanay, Hervé, Trinquet, Eric, Daoudi, Mehdi, Combadière, Christophe, Deterre, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662081/
https://ncbi.nlm.nih.gov/pubmed/18725411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802638200
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