Fibrinogen-elongated γ Chain Inhibits Thrombin-induced Platelet Response, Hindering the Interaction with Different Receptors

The expression of the elongated fibrinogen γ chain, termed γ′, derives from alternative splicing of mRNA and causes an insertion sequence of 20 amino acids. This insertion domain interacts with the anion-binding exosite (ABE)-II of thrombin. This study investigated whether and how γ′ chain binding t...

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Autori principali: Lancellotti, Stefano, Rutella, Sergio, De Filippis, Vincenzo, Pozzi, Nicola, Rocca, Bianca, De Cristofaro, Raimondo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Soggetti:
Enzyme Catalysis and Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662079/
https://ncbi.nlm.nih.gov/pubmed/18779330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803659200
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