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The Role of Electrostatic Interactions in Thrombin Binding to the Fibrinogen γ′ Chain
Thrombin binds to the highly anionic fibrinogen γ′ chain through anion-binding exosite II. This binding profoundly alters thrombin’s ability to cleave substrates, including fibrinogen, factor VIII, and PAR1. However, it is unknown whether this interaction is due mainly to general electrostatic compl...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3943421/ https://ncbi.nlm.nih.gov/pubmed/22439748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2016519 |
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