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Identification of an Alternative Mechanism of Degradation of the Hypoxia-inducible Factor-1α

The hypoxia-inducible factor-1α (HIF-1α) is a master regulator of the cellular response to decreased oxygen levels. This transcription factor is highly unstable at normal oxygen concentrations and is rapidly stabilized by hypoxia. At normoxia two specific proline residues (Pro(402) and Pro(563)) of...

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Autori principali: André, Helder, Pereira, Teresa S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662024/
https://ncbi.nlm.nih.gov/pubmed/18694926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805919200
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