Mammalian Kinesin-3 Motors Are Dimeric In Vivo and Move by Processive Motility upon Release of Autoinhibition

Kinesin-3 motors drive the transport of synaptic vesicles and other membrane-bound organelles in neuronal cells. In the absence of cargo, kinesin motors are kept inactive to prevent motility and ATP hydrolysis. Current models state that the Kinesin-3 motor KIF1A is monomeric in the inactive state an...

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Bibliografiske detaljer
Main Authors: Hammond, Jennetta W, Cai, Dawen, Blasius, T. Lynne, Li, Zhe, Jiang, Yuyang, Jih, Gloria T, Meyhofer, Edgar, Verhey, Kristen J
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661964/
https://ncbi.nlm.nih.gov/pubmed/19338388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000072
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