Glycogen Synthase Kinase 3 (GSK-3) Inhibition Slows Mitochondrial Adenine Nucleotide Transport and Regulates VDAC phosphorylation

Inhibition of GSK-3 reduces ischemia-reperfusion injury by mechanisms that involve the mitochondria. The goal of this study was to explore possible molecular targets and mechanistic basis of this cardioprotective effect. In perfused rat hearts, treatment with GSK inhibitors prior to ischemia signifi...

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Bibliographic Details
Main Authors: Das, Samarjit, Wong, Renee, Rajapakse, Nishadi, Murphy, Elizabeth, Steenbergen, Charles
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661871/
https://ncbi.nlm.nih.gov/pubmed/18802025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.178970
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