Detection of K-Ras mutations in tumour samples of patients with non-small cell lung cancer using PNA-mediated PCR clamping

Non-small cell lung cancers (NSCLC), in particular adenocarcinoma, are often mixed with normal cells. Therefore, low sensitivity of direct sequencing used for K-Ras mutation analysis could be inadequate in some cases. Our study focused on the possibility to increase the detection of K-Ras mutations...

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Detalhes bibliográficos
Main Authors: Beau-Faller, M, Legrain, M, Voegeli, A-C, Guérin, E, Lavaux, T, Ruppert, A-M, Neuville, A, Massard, G, Wihlm, J-M, Quoix, E, Oudet, P, Gaub, M P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661785/
https://ncbi.nlm.nih.gov/pubmed/19293811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604925
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