Ciliary Neurotrophic Factor Stimulates Muscle Glucose Uptake by a PI3-Kinase–Dependent Pathway That Is Impaired With Obesity

OBJECTIVE: Ciliary neurotrophic factor (CNTF) reverses muscle insulin resistance by increasing fatty acid oxidation through gp130-LIF receptor signaling to the AMP-activated protein kinase (AMPK). CNTF also increases Akt signaling in neurons and adipocytes. Because both Akt and AMPK regulate glucose...

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Detalhes bibliográficos
Main Authors: Steinberg, Gregory R., Watt, Matthew J., Ernst, Matthias, Birnbaum, Morris J., Kemp, Bruce E., Jørgensen, Sebastian Beck
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661597/
https://ncbi.nlm.nih.gov/pubmed/19136654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0659
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