Do Non-HLA Genes Influence Development of Persistent Islet Autoimmunity and Type 1 Diabetes in Children With High-Risk HLA-DR,DQ Genotypes?

OBJECTIVE: Specific alleles of non-HLA genes INS, CTLA-4, and PTPN22 have been associated with type 1 diabetes. We examined whether some of these alleles influence development of islet autoimmunity or progression from persistent islet autoimmunity to type 1 diabetes in children with high-risk HLA-DR...

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Detalhes bibliográficos
Main Authors: Steck, Andrea K., Zhang, Weiming, Bugawan, Teodorica L., Barriga, Katherine J., Blair, Alan, Erlich, Henry A., Eisenbarth, George S., Norris, Jill M., Rewers, Marian J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661592/
https://ncbi.nlm.nih.gov/pubmed/19188433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1179
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