TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet β-Cells

OBJECTIVE: Polymorphisms in the human TCF7L2 gene are associated with reduced insulin secretion and an increased risk of type 2 diabetes. However, the mechanisms by which TCF7L2 affect insulin secretion are still unclear. We define the effects of TCF7L2 expression level on mature β-cell function and...

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Autores principales: da Silva Xavier, Gabriela, Loder, Merewyn K., McDonald, Angela, Tarasov, Andrei I., Carzaniga, Raffaella, Kronenberger, Katrin, Barg, Sebastian, Rutter, Guy A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2009
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661588/
https://ncbi.nlm.nih.gov/pubmed/19168596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1187
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