A Central Role for CK1 in Catalyzing Phosphorylation of the p53 Transactivation Domain at Serine 20 after HHV-6B Viral Infection

The tumor suppressor protein p53 is activated by distinct cellular stresses including radiation, hypoxia, type I interferon, and DNA/RNA virus infection. The transactivation domain of p53 contains a phosphorylation site at Ser(20) whose modification stabilizes the binding of the transcriptional co-a...

Full description

Saved in:
Bibliographic Details
Main Authors: MacLaine, Nicola J., Øster, Bodil, Bundgaard, Bettina, Fraser, Jennifer A., Buckner, Carolyn, Lazo, Pedro A., Meek, David W., Höllsberg, Per, Hupp, Ted R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661408/
https://ncbi.nlm.nih.gov/pubmed/18669630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804433200
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items