Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination

BACKGROUND: The expression and activity of P-glycoproteins due to genetic or environmental factors may have a significant impact on drug disposition, drug effectiveness or drug toxicity. Hence, characterization of drug disposition over a wide range of conditions of these membrane transporters activi...

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Dades bibliogràfiques
Autors principals: Fenneteau, Frédérique, Turgeon, Jacques, Couture, Lucie, Michaud, Véronique, Li, Jun, Nekka, Fahima
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2009
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661039/
https://ncbi.nlm.nih.gov/pubmed/19146691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4682-6-2
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