Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

Macrophage-specific expression of Arginase-1 is commonly believed to promote inflammation, fibrosis, and wound healing by enhancing L-proline, polyamine, and Th2 cytokine production. Here, however, we show that macrophage-specific Arg1 functions as an inhibitor of inflammation and fibrosis following...

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Main Authors: Pesce, John T., Ramalingam, Thirumalai R., Mentink-Kane, Margaret M., Wilson, Mark S., El Kasmi, Karim C., Smith, Amber M., Thompson, Robert W., Cheever, Allen W., Murray, Peter J., Wynn, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2009
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660425/
https://ncbi.nlm.nih.gov/pubmed/19360123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000371
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