A functional variant in TIRAP, also known as MAL, and protection against invasive pneumococcal disease, bacteraemia, malaria and tuberculosis

Toll-like receptors (TLRs) and members of their signalling pathway play an important role in the initiation of the innate immune response to a wide variety of pathogens1,2,3. The adaptor protein TIRAP mediates downstream signalling of TLR-2 and -44,5,6. We report a case-control genetic association s...

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Detalhes bibliográficos
Main Authors: Khor, Chiea C., Chapman, Stephen J., Vannberg, Fredrik O, Dunne, Aisling, Murphy, Caroline, Ling, Edmund Y, Frodsham, Angela J., Walley, Andrew J, Kyrieleis, Otto, Khan, Amir, Aucan, Christophe, Segal, Shelley, Moore, Catrin E., Knox, Kyle, Campbell, Sarah J., Lienhardt, Christian, Scott, Anthony, Aaby, Peter, Sow, Oumou Y., Grignani, Robert T., Sillah, Jackson, Sirugo, Girogio, Peshu, Nobert, Williams, Thomas N., Maitland, Kathryn, Davies, Robert J. O., Kwiatkowski, Dominic P., Day, Nicholas P., Yala, Djamel, Crook, Derrick W., Marsh, Kevin, Berkley, James A, O’Neill, Luke A.J., Hill, Adrian V. S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660299/
https://ncbi.nlm.nih.gov/pubmed/17322885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng1976
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