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TGF-β upregulation drives tertiary lymphoid organ formation and kidney dysfunction in calcineurin A-α heterozygous mice

Calcineurin is an important intracellular signaling molecule which can be inhibited by cyclosporin resulting in immune suppression and nephrotoxicity. Previously, we reported that homozygous loss of the α isoform of calcineurin impairs kidney development and function and mimics many features of cycl...

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Detalhes bibliográficos
Main Authors: Kelly, Fiona M., Reddy, Ramesh N., Roberts, Brian R., Gangappa, Shivaprakash, Williams, Ifor R., Gooch, Jennifer L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660193/
https://ncbi.nlm.nih.gov/pubmed/19129256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90629.2008
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