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Probing the Flexibility of Large Conformational Changes in Protein Structures through Local Perturbations

Protein conformational changes and dynamic behavior are fundamental for such processes as catalysis, regulation, and substrate recognition. Although protein dynamics have been successfully explored in computer simulation, there is an intermediate-scale of motions that has proven difficult to simulat...

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Detalhes bibliográficos
Main Authors: Ho, Bosco K., Agard, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660149/
https://ncbi.nlm.nih.gov/pubmed/19343225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000343
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