CDKN1C (p57(KIP2)) Is a Direct Target of EZH2 and Suppressed by Multiple Epigenetic Mechanisms in Breast Cancer Cells

CDKN1C (encoding tumor suppressor p57(KIP2)) is a cyclin-dependent kinase (CDK) inhibitor whose family members are often transcriptionally downregulated in human cancer via promoter DNA methylation. In this study, we show that CDKN1C is repressed in breast cancer cells mainly through histone modific...

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Main Authors: Yang, Xiaojing, Karuturi, R. K. Murthy, Sun, Feng, Aau, Meiyee, Yu, Kun, Shao, Rongguang, Miller, Lance D., Tan, Patrick Boon Ooi, Yu, Qiang
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659786/
https://ncbi.nlm.nih.gov/pubmed/19340297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005011
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