Proapoptotic Activity and Chemosensitizing Effect of the Novel Akt Inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-Cell Acute Lymphoblastic Leukemia

Constitutively activated AKT kinase is a common feature of T-cell acute lymphoblastic leukemia (T-ALL). Here, we report that the novel AKT inhibitor (2S)-1-(1H-indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) leads to rapid cell death of T-ALL lines and patient samp...

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Detalhes bibliográficos
Main Authors: Falà, Federica, Blalock, William L., Tazzari, Pier Luigi, Cappellini, Alessandra, Chiarini, Francesca, Martinelli, Giovanni, Tafuri, Agostino, McCubrey, James A., Cocco, Lucio, Martelli, Alberto M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659779/
https://ncbi.nlm.nih.gov/pubmed/18577685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.047639
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