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Gene expression and internalization following vector adsorption to immobilized proteins: dependence on protein identity and density

BACKGROUND: Gene delivery by non-specific adsorption of non-viral vectors to protein-coated surfaces can reduce the amount of DNA required, and also increase transgene expression and the number of cells expressing the transgene. The protein on the surface mediates cell adhesion and vector immobiliza...

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Main Authors: Bengali, Zain, Rea, Jennifer C., Shea, Lonnie D.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659664/
https://ncbi.nlm.nih.gov/pubmed/17533618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jgm.1058
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