A Variant Mimicking Hyperphosphorylated 4E-BP Inhibits Protein Synthesis in a Sea Urchin Cell-Free, Cap-Dependent Translation System

BACKGROUND: 4E-BP is a translational inhibitor that binds to eIF4E to repress cap-dependent translation initiation. This critical protein:protein interaction is regulated by the phosphorylation of 4E-BP. Hypophosphorylated 4E-BP binds to eIF4E and inhibits cap-dependent translation, whereas hyperpho...

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Autors principals: Oulhen, Nathalie, Boulben, Sandrine, Bidinosti, Michael, Morales, Julia, Cormier, Patrick, Cosson, Bertrand
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659438/
https://ncbi.nlm.nih.gov/pubmed/19333389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005070
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