PIK3CA Mutation Is Associated With Poor Prognosis Among Patients With Curatively Resected Colon Cancer

PURPOSE: PIK3CA mutation and subsequent activation of the AKT pathway play an important role in colorectal carcinogenesis. However, little is known about the prognostic role of PIK3CA mutation in colon cancer. PATIENTS AND METHODS: Using 450 resectable colon cancers (stage I to III) in two independe...

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Detalhes bibliográficos
Main Authors: Ogino, Shuji, Nosho, Katsuhiko, Kirkner, Gregory J., Shima, Kaori, Irahara, Natsumi, Kure, Shoko, Chan, Andrew T., Engelman, Jeffrey A., Kraft, Peter, Cantley, Lewis C., Giovannucci, Edward L., Fuchs, Charles S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2009
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659340/
https://ncbi.nlm.nih.gov/pubmed/19237633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2008.18.6544
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