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Evidence that Intestinal Glucagon-Like Peptide-1 Plays a Physiological Role in Satiety

A physiological role in satiety is proposed for glucagon-like peptide-1 (GLP-1), secreted by the distal intestine in response to ingested nutrients. Here we report that in rats, ip injection of the GLP-1 receptor (GLP-1-R) antagonist exendin 9-39 (Ex9) elicited hyperphagia, but only at times of day...

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Detalhes bibliográficos
Main Authors: Williams, Diana L., Baskin, Denis G., Schwartz, Michael W.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659282/
https://ncbi.nlm.nih.gov/pubmed/19074583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-1045
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