Versican/PG-M Assembles Hyaluronan into Extracellular Matrix and Inhibits CD44-mediated Signaling toward Premature Senescence in Embryonic Fibroblasts

Versican/PG-M is a large chondroitin sulfate proteoglycan of the extracellular matrix which interacts with hyaluronan at the N-terminal G1 domain, composed of A, B, and B′ subdomains. Recently, we generated knock-in mice Cspg2(Δ3/Δ3), whose versican, without the A subdomain, has decreased hyaluronan...

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Autors principals: Suwan, Keittisak, Choocheep, Kanyamas, Hatano, Sonoko, Kongtawelert, Prachya, Kimata, Koji, Watanabe, Hideto
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Glycobiology and Extracellular Matrices
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659218/
https://ncbi.nlm.nih.gov/pubmed/19164294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806927200
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