Differential Processing of α- and β-Defensin Precursors by Matrix Metalloproteinase-7 (MMP-7)

Proteolytic processing of defensins is a critical mode of posttranslational regulation of peptide activity. Because mouse α-defensin precursors are cleaved and activated by matrix metalloproteinase-7 (MMP-7), we determined if additional defensin molecules, namely human neutrophil defensin pro-HNP-1...

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Bibliographische Detailangaben
Hauptverfasser: Wilson, Carole L., Schmidt, Amy P., Pirilä, Emma, Valore, Erika V., Ferri, Nicola, Sorsa, Timo, Ganz, Tomas, Parks, William C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Enzyme Catalysis and Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659188/
https://ncbi.nlm.nih.gov/pubmed/19181662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809744200
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