Synaptic transmission block by presynaptic injection of oligomeric amyloid beta

Early Alzheimer's disease (AD) pathophysiology is characterized by synaptic changes induced by degradation products of amyloid precursor protein (APP). The exact mechanisms of such modulation are unknown. Here, we report that nanomolar concentrations of intraaxonal oligomeric (o)Aβ42, but not o...

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Bibliografiske detaljer
Main Authors: Moreno, Herman, Yu, Eunah, Pigino, Gustavo, Hernandez, Alejandro I., Kim, Natalia, Moreira, Jorge E., Sugimori, Mutsuyuki, Llinás, Rodolfo R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659170/
https://ncbi.nlm.nih.gov/pubmed/19304802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900944106
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