Human-specific gain of function in a developmental enhancer

Changes in gene regulation are thought to have contributed to the evolution of human development. However, in vivo evidence for uniquely human developmental regulatory function has remained elusive. In transgenic mice, a conserved noncoding sequence (HACNS1) that evolved extremely rapidly in humans...

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Main Authors: Prabhakar, Shyam, Visel, Axel, Akiyama, Jennifer A., Shoukry, Malak, Lewis, Keith D., Holt, Amy, Plajzer-Frick, Ingrid, Morrison, Harris, FitzPatrick, David R., Afzal, Veena, Pennacchio, Len A., Rubin, Edward M., Noonan, James P.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658639/
https://ncbi.nlm.nih.gov/pubmed/18772437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1159974
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