HIV-1 Nef Inhibits Lipopolysaccharide-induced IL-12p40 Expression by Inhibiting JNK-activated NFκB in Human Monocytic Cells

Impaired cellular immunity caused by decreased production of Th1-type cytokines, including interleukin-12 (IL-12) is a major feature of HIV-1-associated immunodeficiency and acquired immunodeficiency syndrome. IL-12p40, an inducible subunit shared between IL-12 and IL-23, plays a critical role in th...

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Detalhes bibliográficos
Main Authors: Ma, Wei, Mishra, Sasmita, Gajanayaka, Niranjala, Angel, Jonathan B., Kumar, Ashok
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658052/
https://ncbi.nlm.nih.gov/pubmed/19019824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710013200
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