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Exploring and dissecting genome-wide gene expression responses of Penicillium chrysogenum to phenylacetic acid consumption and penicillinG production

BACKGROUND: Since the discovery of the antibacterial activity of penicillin by Fleming 80 years ago, improvements of penicillin titer were essentially achieved by classical strain improvement through mutagenesis and screening. The recent sequencing of Penicillium chrysogenum strain Wisconsin1255-54...

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Autors principals: Harris, Diana M, van der Krogt, Zita A, Klaassen, Paul, Raamsdonk, Leonie M, Hage, Susanne, van den Berg, Marco A, Bovenberg, Roel AL, Pronk, Jack T, Daran, Jean-Marc
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2657799/
https://ncbi.nlm.nih.gov/pubmed/19203396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-10-75
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