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Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA

In metazoans, nuclear export of bulk mRNA is mediated by Tap-p15, a conserved heterodimeric export receptor that cooperates with adaptor RNA-binding proteins. In this article, we show that Thoc5, a subunit of the mammalian TREX complex, binds to a distinct surface on the middle (Ntf2-like) domain of...

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Main Authors: Katahira, Jun, Inoue, Hitomi, Hurt, Ed, Yoneda, Yoshihiro
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2657587/
https://ncbi.nlm.nih.gov/pubmed/19165146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.5
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