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Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP
Adaptor proteins stimulate the nuclear export of mRNA, but their mechanism of action remains unclear. Here, we show that REF/ALY binds mRNA; but upon formation of a ternary complex with TAP the RNA is transferred from REF to TAP, and overexpression of TAP displaces REF from mRNA in vivo. RNA is also...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2278192/ https://ncbi.nlm.nih.gov/pubmed/18364396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709167105 |
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